Specialized pro-resolving mediators as modulators of immune responses

Abstract

Specialized pro-resolving mediators (SPMs) are endogenous small molecules produced mainly from dietary omega-3 polyunsaturated fatty acids by both structural cells and cells of the active and innate immune systems. Specialized pro-resolving mediators have been shown to both limit acute inflammation and promote resolution and return to homeostasis following infection or injury. There is growing evidence that chronic immune disorders are characterized by deficiencies in resolution and SPMs have significant potential as novel therapeutics to prevent and treat chronic inflammation and immune system disorders. This review focuses on important breakthroughs in understanding how SPMs are produced by, and act on, cells of the adaptive immune system, specifically macrophages, B cells and T cells. We also highlight recent evidence demonstrating the potential of SPMs as novel therapeutic agents in topics including immunization, autoimmune disease and transplantation.

Keywords: Adaptive immunity; Autoimmunity; B cells; Docosahexaenoic acid; Eicosapentaenoic acid; Inflammation; Lipoxin; Macrophages; Maresin; Protectin; Resolution; Resolvin; Specialized pro-resolving mediators; T cells.