Multi-modality connectome-based predictive modeling of individualized compulsions in obsessive-compulsive disorder

Abstract

Background: While previous neuroimaging studies are mainly focused on dichotomous classification of obsessive-compulsive disorder (OCD) from controls, predicting continuous severity of specific symptom is also pivotal to clinical diagnosis and treatment.

Methods: We applied a machine-learning approach, connectome-based predictive modeling, on functional and structural brain networks constructed from resting-state functional magnetic resonance imaging and diffusion tensor imaging data to decode compulsions and obsessions of fifty-four patients with OCD.

Results: We successfully predicted individualized compulsions with a positive model of structural brain network and with a negative model of functional brain network. The structural predictive brain network comprises the motor cortex, cerebellum and limbic lobe, which are involved in basic motor control, motor execution and emotion processing, respectively. The functional predictive brain network is composed by the prefrontal and limbic systems which are related to cognitive and affective control. Computational lesion analysis shows that functional connectivity among the salience network (SN), the frontal parietal network and the default mode network, as well as structural connectivity within the SN are vital in the individualized prediction of compulsions in OCD.

Limitations: There was no external validation of large samples to test the robustness of our predictive model.

Conclusions: These findings provide the first evidence for the predictive role of the triple network model in individualized compulsions and have important implications in diagnosis, prognosis and treatment of patients with OCD.

Keywords: Compulsions; Connectome-based predictive modeling (CPM); DTI; Obsessive-compulsive disorder (OCD); Resting-state fMRI.