Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

José Diogo S Souza; Maíra Fassoni-Ribeiro; Rayssa Miranda Batista; Juliana Mayumi Ushirohira; Antonio W Zuardi; Francisco S Guimarães; Alline C Campos; Flávia de Lima Osório; Daniel Elias; Cacilda S Souza; AndRea A Fassoni; Jaime E C Hallak; José Alexandre S Crippa

doi:10.3389/fphar.2022.881617

Case Report: Cannabidiol-Induced Skin Rash: A Case Series and Key Recommendations

Front Pharmacol. 2022 May 19:13:881617. doi: 10.3389/fphar.2022.881617. eCollection 2022.

Authors

José Diogo S Souza¹, Maíra Fassoni-Ribeiro², Rayssa Miranda Batista³, Juliana Mayumi Ushirohira¹, Antonio W Zuardi^{1

4}, Francisco S Guimarães^{4

5}, Alline C Campos⁵, Flávia de Lima Osório^{1

4}, Daniel Elias³, Cacilda S Souza³, AndRea A Fassoni⁶, Jaime E C Hallak^{1

4}, José Alexandre S Crippa^{1

4}

Affiliations

¹ Department of Neurosciences and Behavior, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
² Department of Dermatology, São Paulo Federal University, São Paulo, Brazil.
³ Division of Dermatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
⁴ National Institute of Science and Technology-Translational Medicine, Ribeirão Preto, Brazil.
⁵ Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
⁶ Anatomed Laboratory, Bauru, Brazil.

Abstract

Cannabidiol (CBD) is a non-psychotomimetic constituent of the Cannabis plant, with potential therapeutic properties for many physical and neuropsychiatric conditions. Isolated CBD has been suggested to have favorable safety and tolerability. Although CBD-related rash is described, few case reports are well documented in the literature, and usually, CBD was used concomitantly with other medications. Thus, we report four women who presented a skin rash after ongoing CBD use. Other causes of these skin rashes were ruled out after conducting an extensive viral and serological detection panel, and three patients had their lesions biopsied. Two patients were re-exposed to the vehicle (MCT) without developing a new skin rash. Therefore, clinicians must be aware of this potential adverse effect of CBD use.

Keywords: cannabidiol; case report; case series; drug interaction; side effects; skin rash.

Publication types

Case Reports