Malignant giant cell tumor of toe: A case report and review of literature

Medicine (Baltimore). 2022 Jun 3;101(22):e29471. doi: 10.1097/MD.0000000000029471.


Introduction: A giant cell tumor of soft tissue (GCST) is a benign soft tissue tumor that often occurs subcutaneously in the extremities. Rare cases of malignant GCST have been reported, but its pathogenesis remains unclear.

Patients concerns: We report a case of a 68-year-old man who noticed a painless mass on his second toe one and a half years ago. He visited the Department of Dermatology at our hospital. Magnetic resonance imaging revealed a soft tissue tumor, surrounding the distal aspect of the second toe.

Diagnosis: A biopsy of the tumor was performed by a dermatologist, and it revealed a malignant giant cell tumor of the toe.

Interventions: He was referred to our department and underwent lay amputation for wide-margin resection.

Outcomes: No recurrence or metastasis was observed 5 years after treatment.

Conclusion: : Malignant GCST should be treated with wide-margin resection immediately after its diagnosis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Amputation, Surgical
  • Giant Cell Tumors*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Soft Tissue Neoplasms* / diagnosis
  • Soft Tissue Neoplasms* / surgery
  • Toes / surgery