COVID-19 in Children

Pediatr Clin North Am. 2022 Jun;69(3):547-571. doi: 10.1016/j.pcl.2022.01.013. Epub 2022 Feb 2.


Coronavirus disease 2019 (COVID-19) is an ongoing pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. More than 5 million children have been infected in the United States. Risk factors for more severe disease progression include obesity, pulmonary disease, gastrointestinal disorders, and neurologic comorbidities. Children with COVID-19 are admitted to the pediatric intensive care unit because of severe acute COVID-19 illness or COVID-19-associated multisystem inflammatory syndrome in children. The delta surge of 2021 was responsible for an increased disease burden in children and points to the key role of vaccinating children against this sometimes-deadly disease.

Keywords: ARDS; COVID-19; Epidemiology; MIS-C; Pediatric COVID; Risk factors; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • COVID-19* / complications
  • COVID-19* / epidemiology
  • Child
  • Humans
  • Intensive Care Units, Pediatric
  • Pandemics
  • SARS-CoV-2
  • Systemic Inflammatory Response Syndrome
  • United States / epidemiology

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related