Stereotactic surgeries for abuse syndromes: Patient selection and results

Prog Brain Res. 2022;272(1):85-103. doi: 10.1016/bs.pbr.2022.03.006. Epub 2022 May 18.

Abstract

It is known that in present time heroin addiction is the most widespread and difficult to treat. It includes two factors: physical and psychological addiction. The vast majority of patients remained mentally addicted to drugs after physical drug addiction has been eliminated and the organism has been completely detoxed. It is an indomitable desire to take drugs. Neurophysiological mechanisms are in base of psychological dependence. It is similar to those that implement obsessive states (obsessive-compulsive disorders). The central role in these neurophysiological mechanisms is played by limbic system of the brain that provides emotional and motivational behavior of humans (and animals). It was shown that the treatment of medical-resistant forms of obsessive-compulsive disorders requires stereotactic impacts on various structures of the limbic system, including cingulate gyrus. According to literature data, there was several hundred stereotactic effects on the cingulate gyrus in the world. About 1000 stereotactic operations have been performed in our country as a mental addiction of heroin dependent patients' treatment. The efficiency was of about 70%.

Keywords: Cingulum bundle; Drug addiction; Limbic system; Obsessive-compulsive disorder; Opioid addiction; Psychiatric neurosurgery; Stereotactic capsulotomy; Stereotactic cingulotomy; Stereotactic cryodestruction; Stereotactic imaging.

MeSH terms

  • Animals
  • Gyrus Cinguli / surgery
  • Humans
  • Limbic System / surgery
  • Patient Selection
  • Psychosurgery* / methods
  • Substance-Related Disorders* / surgery
  • Syndrome