Carboxytherapy in dermatology

Clin Dermatol. 2022 May-Jun;40(3):305-309. doi: 10.1016/j.clindermatol.2021.08.020. Epub 2021 Aug 20.


Carboxytherapy is a medical technique during which a sterile gas-carbon dioxide-is injected into the subdermal tissue. The utility of carbon dioxide injections has enhanced the practical relevance of carboxytherapy as a method for the management of multiple disorders. We have evaluated its use in the treatment of dermatologic conditions by searching electronic databases (ie, MEDLINE and PubMed) for contributions in the English language through January 2021. Carboxytherapy provides an attractive aesthetic option in skin rejuvenation, atrophic scars, striae distensae (stretch marks), cellulite-fibrolipodystrophy adhesions after liposuction, and certain types of alopecia. We discuss the drawbacks of the procedure including inadvertent lipolysis, long-lasting emphysema, and suboptimal outcomes.

MeSH terms

  • Carbon Dioxide / therapeutic use
  • Cellulite*
  • Dermatology*
  • Humans
  • Skin
  • Striae Distensae*


  • Carbon Dioxide