Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018

doi:10.3389/fnut.2022.903493

. 2022 May 20:9:903493.

doi: 10.3389/fnut.2022.903493. eCollection 2022.

Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018

Jungao Huang^{1

2}, Liqin Hu², Juan Yang¹

Affiliations

¹ Key Laboratory of Environment and Disease-Related Gene, Ministry of Education, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
² Ganzhou Maternal and Child Health Hospital, Ganzhou, China.

PMID: 35669066
PMCID: PMC9165529
DOI: 10.3389/fnut.2022.903493

Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018

Jungao Huang et al. Front Nutr. 2022.

. 2022 May 20:9:903493.

doi: 10.3389/fnut.2022.903493. eCollection 2022.

Authors

Jungao Huang^{1

2}, Liqin Hu², Juan Yang¹

Affiliations

¹ Key Laboratory of Environment and Disease-Related Gene, Ministry of Education, Department of Cell Biology and Genetics, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
² Ganzhou Maternal and Child Health Hospital, Ganzhou, China.

PMID: 35669066
PMCID: PMC9165529
DOI: 10.3389/fnut.2022.903493

Abstract

Aims/hypothesis: This study aimed to explore whether household pesticide exposure in the general population increased the risk of developing type 2 diabetes and whether intake of dietary magnesium could lower type 2 diabetes from household pesticide exposure.

Methods: For this cross-sectional study, we obtained the data of 9,187 United States adults from the National Health and Nutrition Examination Surveys, 2007-2018. Participants were subdivided into two groups based on the amount of daily dietary magnesium in the population: low group: <175 mg/day and high group: ≥175 mg/day. Using multivariable logistic regression analysis, we evaluated the relationship between pesticide exposure in the home and type 2 diabetes.

Results: Compared to those unexposed at home, individuals who were exposed to pesticides in their households had a relatively higher odds ratio for type 2 diabetes (OR = 1.22, 95% CI: 1.04-1.44). The association of pesticide exposure in the home with the incidence of type 2 diabetes was different for low and high dietary magnesium groups, OR = 1.66, 95% Cl: 1.19-2.33 vs. OR = 1.1, 95% Cl: 0.92-1.32, respectively. An interaction (P = 0.035) between household pesticide exposure and magnesium intake, suggested that high dietary magnesium intake may reduce the risk of developing type 2 diabetes from pesticide exposure.

Conclusions: Household pesticide exposure in the general population is associated with an elevated risk of type 2 diabetes. We report for the first time possible clinical relevance in that high magnesium intake may ameliorate the increased risk of type 2 diabetes from pesticide exposure.

Keywords: dietary magnesium intake; general population; household pesticide exposure; oxidative stress; type 2 diabetes.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**Figure 1**
The flow chart of the study.

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References

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1. Sharafi Z, Ehrampoush MH, Salehi-Abargouei A, Sakhvidi MJZ, Askarishahi M, Mirzaei M, et al. . Investigation of the association between pesticide exposure and the prevalence of type 2 diabetes in Shahedieh population in Yazd. Environ Sci Pollut Res Int. (2021) 28:43394–401. 10.1007/s11356-021-13821-w - DOI - PubMed

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[1] Juntarawijit C, Juntarawijit Y. Association between diabetes and pesticides: a case-control study among Thai farmers. Environ Health Prev Med. (2018) 23:3. 10.1186/s12199-018-0692-5 - DOI - PMC - PubMed

[2] Juntarawijit C, Juntarawijit Y. Association between diabetes and pesticides: a case-control study among Thai farmers. Environ Health Prev Med. (2018) 23:3. 10.1186/s12199-018-0692-5 - DOI - PMC - PubMed

[3] Chen H, Chen L, Hao G. Exercise attenuates the association between household pesticide exposure and depressive symptoms: evidence from NHANES, 2005–2014. Environ Res. (2020) 188:109760. 10.1016/j.envres.2020.109760 - DOI - PubMed

[4] Chen H, Chen L, Hao G. Exercise attenuates the association between household pesticide exposure and depressive symptoms: evidence from NHANES, 2005–2014. Environ Res. (2020) 188:109760. 10.1016/j.envres.2020.109760 - DOI - PubMed

[5] Starling AP, Umbach DM, Kamel F, Long S, Sandler DP, Hoppin JA. Pesticide use and incident diabetes among wives of farmers in the agricultural health study. Occup Environ Med. (2014) 71:629–35. 10.1136/oemed-2013-101659 - DOI - PMC - PubMed

[6] Starling AP, Umbach DM, Kamel F, Long S, Sandler DP, Hoppin JA. Pesticide use and incident diabetes among wives of farmers in the agricultural health study. Occup Environ Med. (2014) 71:629–35. 10.1136/oemed-2013-101659 - DOI - PMC - PubMed

[7] Montgomery MP, Kamel F, Saldana TM, Alavanja MC, Sandler DP. Incident diabetes and pesticide exposure among licensed pesticide applicators: agricultural health study, 1993–2003. Am J Epidemiol. (2008) 167:1235–46. 10.1093/aje/kwn028 - DOI - PMC - PubMed

[8] Montgomery MP, Kamel F, Saldana TM, Alavanja MC, Sandler DP. Incident diabetes and pesticide exposure among licensed pesticide applicators: agricultural health study, 1993–2003. Am J Epidemiol. (2008) 167:1235–46. 10.1093/aje/kwn028 - DOI - PMC - PubMed

[9] Sharafi Z, Ehrampoush MH, Salehi-Abargouei A, Sakhvidi MJZ, Askarishahi M, Mirzaei M, et al. . Investigation of the association between pesticide exposure and the prevalence of type 2 diabetes in Shahedieh population in Yazd. Environ Sci Pollut Res Int. (2021) 28:43394–401. 10.1007/s11356-021-13821-w - DOI - PubMed

[10] Sharafi Z, Ehrampoush MH, Salehi-Abargouei A, Sakhvidi MJZ, Askarishahi M, Mirzaei M, et al. . Investigation of the association between pesticide exposure and the prevalence of type 2 diabetes in Shahedieh population in Yazd. Environ Sci Pollut Res Int. (2021) 28:43394–401. 10.1007/s11356-021-13821-w - DOI - PubMed

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Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018

Affiliations

Dietary Magnesium Intake Ameliorates the Association Between Household Pesticide Exposure and Type 2 Diabetes: Data From NHANES, 2007-2018

Authors

Affiliations

Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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