Increased airway resistance can be related to the decrease in the functional capacity in obese women

PLoS One. 2022 Jun 7;17(6):e0267546. doi: 10.1371/journal.pone.0267546. eCollection 2022.

Abstract

Background and objective: Obesity can increase the airways resistance, mainly in the periphery, leading to dyspnea perception that can impair the functional capacity. This study aimed to analyze if airways resistance could be related to the walking capacity of women with morbid obesity.

Methods: Thirty-seven women with grade III obesity in preoperative bariatric surgery were evaluated using the spirometry test, impulse oscillometry system (IOS), and six-minute walk test (6MWT). Additionally, data about their daily dyspnea perception and physical activity level were collected.

Results: Variables of the spirometry test did not detect ventilator disorders. Compared to the predicted values, the IOS identified significant increase in airways resistance (kPa/L/s) (R5: 0.36 (0.34; 0.36) and 0.53 (0.47; 0.61); R20: 0.30 (0.28; 0.30) and 0.41 (0.35; 0.45); R5-20: 0.06 (0.06; 0.06) and 0.14 (0.10; 0.15); X5: -0.03 (-0.04; -0.01) and -0.20 (-0.27; -0.18), respectively). The distance walked in the 6MWT, 491.4±60.4m was significantly correlated to R5 (rho = -0.41, p = 0.01), R5-20 (rho = -0.52, p = 0.001), and X5 (rho = 0.54, p = 0.0006).

Conclusion: The IOS is able to identify changes in airway resistance even before the onset of symptoms. When evaluated by IOS women with severe obesity and normal spirometry exhibited central and peripheral airways obstruction. The correlations between the IOS and six-minute walk distance suggest that increased peripheral airways resistance could be related to worsening functional capacity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Airway Resistance*
  • Dyspnea
  • Female
  • Forced Expiratory Volume
  • Humans
  • Lung
  • Obesity
  • Oscillometry
  • Pulmonary Disease, Chronic Obstructive*
  • Spirometry

Grants and funding

LP received a sponsorship given by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) – Finance Code 001. https://www.gov.br/capes. ACG received a financial contribution by Conselho Nacional de Desenvolvimento Científico e Tecnológico – Brazil (CNPq) – Process number 306659/2015-8. https://www.cnpq.br. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.