Sample size for testing differences in proportions for the paired-sample design

Biometrics. 1987 Mar;43(1):207-11.


Miettinen (1968, Biometrics 24, 339-352) presented an approximation for power and sample size for testing the differences between proportions in the matched-pair case. Duffy (1984, Biometrics 40, 1005-1015) gave the exact power for this case and showed that Miettinen's approximation tends to slightly overestimate the power or underestimate the sample size necessary for the design power. A simple alternative approximation that is more conservative is presented here. In many cases, the sample size for the independent-sample case provides a conservative approximation for the matched-pair design.

MeSH terms

  • Research Design*
  • Statistics as Topic / methods*