OverProt: secondary structure consensus for protein families

Bioinformatics. 2022 Jul 11;38(14):3648-3650. doi: 10.1093/bioinformatics/btac384.


Summary: Every protein family has a set of characteristic secondary structures. However, due to individual variations, a single structure is not enough to represent the whole family. OverProt can create a secondary structure consensus, showing the general fold of the family as well as its variation. Our server provides precomputed results for all CATH superfamilies and user-defined computations, visualized by an interactive viewer, which shows the secondary structure element type, length, frequency of occurrence, spatial variability and β-connectivity.

Availability and implementation: OverProt Server is freely available at https://overprot.ncbr.muni.cz.

Supplementary information: Supplementary data are available at Bioinformatics online.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computers
  • Consensus
  • Protein Structure, Secondary
  • Proteins* / chemistry
  • Software*


  • Proteins