Role of IL-36 cytokines in psoriasis and other inflammatory skin conditions

Cytokine. 2022 Aug:156:155897. doi: 10.1016/j.cyto.2022.155897. Epub 2022 Jun 6.

Abstract

The IL-36 family of cytokines includes three pro-inflammatory agonists (IL-36α, IL-36β, and IL-36γ) and a receptor antagonist (IL-36Ra), which bind and signal through a heterodimeric receptor composed of IL-36R and the IL-1R accessory protein (IL-1RAcP). Individuals with inactivating mutations in the gene encoding IL-36Ra develop generalized pustular psoriasis, a severe form of psoriasis, a finding which clearly links dysregulated IL-36 pathway activation to inflammatory skin conditions. The purpose of this review is to highlight the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 to a spectrum of inflammatory skin diseases including various forms of psoriasis as well as hidradenitis suppurativa, atopic dermatitis, and allergic contact dermatitis.

Keywords: Allergic contact dermatitis; Atopic dermatitis; Hidradenitis suppurativa; IL-36; Inflammation; Psoriasis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cytokines / metabolism
  • Hidradenitis Suppurativa* / genetics
  • Humans
  • Interleukin-1 / metabolism
  • Interleukins / genetics
  • Interleukins / metabolism
  • Psoriasis* / metabolism
  • Skin / metabolism

Substances

  • Cytokines
  • Interleukin-1
  • Interleukins