Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats

Jin Tian; Jiumeng Sun; Dongyan Li; Ningning Wang; Lifang Wang; Chang Zhang; Xiaorong Meng; Xiang Ji; Marc A Suchard; Xu Zhang; Alexander Lai; Shuo Su; Michael Veit

doi:10.1016/j.celrep.2022.110969

Emerging viruses: Cross-species transmission of coronaviruses, filoviruses, henipaviruses, and rotaviruses from bats

Cell Rep. 2022 Jun 14;39(11):110969. doi: 10.1016/j.celrep.2022.110969. Epub 2022 May 30.

Authors

Jin Tian¹, Jiumeng Sun², Dongyan Li², Ningning Wang², Lifang Wang³, Chang Zhang², Xiaorong Meng⁴, Xiang Ji⁵, Marc A Suchard⁶, Xu Zhang², Alexander Lai⁷, Shuo Su⁸, Michael Veit⁹

Affiliations

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, No. 678 Haping Road, Harbin 150069, China. Electronic address: tianjin@caas.cn.
² College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, No. 1 Weigang, Nanjing 210095, China.
³ College of Veterinary Medicine, China Agricultural University, No. 17 Qinghua Donglu, Beijing 100083, China.
⁴ Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Robert-von-Ostertag-Str. 7, 14163 Berlin, Germany.
⁵ Department of Mathematics, School of Science & Engineering, Tulane University, 6823 St., Charles Avenue, New Orleans, LA 70118, USA.
⁶ Departments of Biomathematics, Human Genetics and Biostatistics, David Geffen School of Medicine and Fielding School of Public Health, University of California, Los Angeles, Geffen Hall 885 Tiverton Drive, Los Angeles, CA 90095, USA.
⁷ School of Science, Technology, Engineering, and Mathematics, Kentucky State University, 400 East Main St., Frankfort, KY 40601, USA.
⁸ College of Veterinary Medicine, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, No. 1 Weigang, Nanjing 210095, China. Electronic address: shuosu@njau.edu.cn.
⁹ Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Robert-von-Ostertag-Str. 7, 14163 Berlin, Germany. Electronic address: michael.veit@fu-berlin.de.

Abstract

Emerging infectious diseases, especially if caused by bat-borne viruses, significantly affect public health and the global economy. There is an urgent need to understand the mechanism of interspecies transmission, particularly to humans. Viral genetics; host factors, including polymorphisms in the receptors; and ecological, environmental, and population dynamics are major parameters to consider. Here, we describe the taxonomy, geographic distribution, and unique traits of bats associated with their importance as virus reservoirs. Then, we summarize the origin, intermediate hosts, and the current understanding of interspecies transmission of Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), SARS-CoV-2, Nipah, Hendra, Ebola, Marburg virus, and rotaviruses. Finally, the molecular interactions of viral surface proteins with host cell receptors are examined, and a comparison of these interactions in humans, intermediate hosts, and bats is conducted. This uncovers adaptive mutations in virus spike protein that facilitate cross-species transmission and risk factors associated with the emergence of novel viruses from bats.

Keywords: CP: Microbiology; RNA virus; bat; interspecies transmission.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
COVID-19*
Chiroptera*
Filoviridae* / genetics
Henipavirus*
Humans
Rotavirus* / genetics
SARS-CoV-2 / genetics
Viruses*