Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review

J Am Coll Cardiol. 2022 Jun 14;79(23):2349-2366. doi: 10.1016/j.jacc.2022.03.379.

Abstract

As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF.

Keywords: NLRP3 inflammasome; atrial fibrillation; inflammation; interleukins.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Atrial Fibrillation* / drug therapy
  • Heart Failure* / etiology
  • Humans
  • Inflammasomes
  • Stroke* / complications
  • Thromboembolism* / etiology

Substances

  • Inflammasomes

Grant support