A 79-Year-Old Woman With Advanced Lung Carcinoma and Bilateral Infiltrates

Chest. 2022 Jun;161(6):e355-e358. doi: 10.1016/j.chest.2022.01.043.


A 79-year-old woman was admitted to the hospital for progressive dyspnea and severe hypoxemia, requiring oxygen supplementation. The dyspnea started approximately 3 to 4 weeks before presentation and was slowly progressive throughout the following weeks. Her medical history mentioned an adenocarcinoma with an epidermal growth factor receptor (EGFR) exon 19 deletion of the lung with metastases to the bones and brain for which treatment with osimertinib was started 14 months earlier. Furthermore, she was treated with rivaroxaban for a first episode of a pulmonary embolism. In the months leading up to her current presentation there were no changes in medication and no use of antibiotics. She had no known exposure to toxic fumes or substances, she was a nonsmoker, and her family history was unremarkable for autoimmune disorders or interstitial lung disease (ILD).

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma* / complications
  • Adenocarcinoma* / diagnosis
  • Aged
  • Dyspnea
  • Female
  • Humans
  • Lung
  • Lung Diseases, Interstitial* / drug therapy
  • Lung Neoplasms* / complications
  • Lung Neoplasms* / drug therapy