Med Clin (Barc). 2022 Aug 26;159(4):195-204. doi: 10.1016/j.medcli.2022.03.009. Epub 2022 Jun 6.
[Article in English, Spanish]


Sarcoidosis is a systemic autoimmune disease that is associated with the development of non-caseating granulomas. The disease especially affects the lymph nodes, lungs, skin and eyes. It is an infrequent but not rare disease, especially in northern Europe, the United States and India. Sarcoidosis affects more women and is diagnosed between the ages of 30 and 50. Etiopathogenically, it is closely linked to environmental factors, especially occupational exposures. Clinically, it stands out for a wide variety of presentation phenotypes (casual diagnosis, involvement of a single organ or systemic presentation). The diagnosis of sarcoidosis is complex and requires the integration of clinical, analytical, radiological, and histolopathogical data carried out by multidisciplinary clinical units. The evolution of the disease is variable, as is the indication for systemic treatment, based on the use of corticosteroids as first-line option, the use of immunosuppressants as second-line therapy, and anti-TNF agents in severe and/or refractory cases.

Keywords: Autoimmune disease; Corticoides; Corticosteroids; Enfermedad autoinmune; Granulomas; Infliximab; Sarcoidosis.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Sarcoidosis* / diagnosis
  • Sarcoidosis* / epidemiology
  • Sarcoidosis* / therapy
  • Skin / pathology
  • Tumor Necrosis Factor Inhibitors*


  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Tumor Necrosis Factor Inhibitors