Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

BMC Gastroenterol. 2022 Jun 9;22(1):292. doi: 10.1186/s12876-022-02361-3.

Abstract

Background: Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly MPM patients.

Methods: From the National Cancer Institute Surveillance Epidemiology End Results (SEER) database, 1492 patients with MPM from 1975 to 2016 were selected and divided into the elderly group (≥ 65) and the adult group (< 65). We compared the clinical-pathological characteristics and treatment methods of the elderly group (N = 665) and the adult group (N = 827). At the same time, we analysed specific selected clinicopathological parameters and prognostic factors for elderly MPM patients.

Results: Compared with the adult group, the elderly group had higher percentages of male patients (P = 0.017) and white patients (P = 0.043) and lower proportions of insured patients (P < 0.001) married patients (P < 0.001), patients with peritoneal tumours (P = 0.006) and patients who underwent surgery (P < 0.001) and chemotherapy (P < 0.001). There was a significant difference in the differentiation grade between the two groups (P = 0.003). Elderly patients had a shorter median survival time than adult patients (6 months vs. 19 months). Uninsured (hazard ratio (HR): 5.187, P = 0.005), sarcomatoid type (HR 3.913, P < 0.001), poorly differentiated (HR 3.900, P < 0.001), distant metastasis (HR 1.735, P = 0.001), no cancer-directed surgery (HR 1.733, P < 0.001), and no chemotherapy (HR 1.532, P < 0.001) were independently associated with poorer prognosis in elderly MPM patients.

Conclusion: Compared with adult patients, elderly MPM patients had a higher male ratio, poor differentiation and relatively conservative treatment. The cancer-specific survival (CSS) rate of elderly MPM patients was significantly lower than that of adult patients. Insurance status, histology type, differentiation grade, stage, surgery status, and chemotherapy status were all independent prognostic factors for elderly MPM patients.

Keywords: Cancer-specific survival; Elderly patients; Malignant peritoneal mesothelioma; Pathological features; Prognostic factors.

MeSH terms

  • Adult
  • Aged
  • Humans
  • Lung Neoplasms* / therapy
  • Male
  • Mesothelioma* / diagnosis
  • Mesothelioma* / therapy
  • Mesothelioma, Malignant*
  • Peritoneal Neoplasms* / secondary
  • Peritoneal Neoplasms* / therapy
  • Pleural Neoplasms* / diagnosis
  • Pleural Neoplasms* / pathology
  • Pleural Neoplasms* / surgery
  • Prognosis