Evaluation of short-term epigenetic age fluctuation

Shohei Komaki; Hideki Ohmomo; Tsuyoshi Hachiya; Yoichi Sutoh; Kanako Ono; Ryohei Furukawa; So Umekage; Yayoi Otsuka-Yamasaki; Shiori Minabe; Akira Takashima; Kozo Tanno; Makoto Sasaki; Atsushi Shimizu

doi:10.1186/s13148-022-01293-9

Evaluation of short-term epigenetic age fluctuation

Clin Epigenetics. 2022 Jun 9;14(1):76. doi: 10.1186/s13148-022-01293-9.

Authors

Shohei Komaki¹, Hideki Ohmomo^{1

2}, Tsuyoshi Hachiya¹, Yoichi Sutoh¹, Kanako Ono¹, Ryohei Furukawa^{1

3}, So Umekage¹, Yayoi Otsuka-Yamasaki¹, Shiori Minabe¹, Akira Takashima¹, Kozo Tanno^{4

5}, Makoto Sasaki^{6

7}, Atsushi Shimizu^{8

9}

Affiliations

¹ Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate, 028-3694, Japan.
² Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan.
³ Department of Biology, Research and Education Center for Natural Sciences, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8521, Japan.
⁴ Division of Clinical Research and Epidemiology, Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
⁵ Department of Hygiene and Preventive Medicine, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan.
⁶ Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan.
⁷ Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan.
⁸ Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate, 028-3694, Japan. ashimizu@iwate-med.ac.jp.
⁹ Division of Biomedical Information Analysis, Institute for Biomedical Sciences, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Shiwa, Iwate, 028-3694, Japan. ashimizu@iwate-med.ac.jp.

Abstract

Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications.

Keywords: Blood DNA methylation; Epigenetic clock; Healthy individuals; Normal condition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics
DNA Methylation*
Epigenesis, Genetic*
Epigenomics
Humans
Infant
Leukocytes, Mononuclear
Male
Monocytes