Animal Models and Helicobacter pylori Infection

J Clin Med. 2022 May 31;11(11):3141. doi: 10.3390/jcm11113141.


Helicobacter pylori colonize the gastric mucosa of at least half of the world's population. Persistent infection is associated with the development of gastritis, peptic ulcer disease, and an increased risk of gastric cancer and gastric-mucosa-associated lymphoid tissue (MALT) lymphoma. In vivo studies using several animal models have provided crucial evidence for understanding the pathophysiology of H. pylori-associated complications. Numerous animal models, such as Mongolian gerbils, transgenic mouse models, guinea pigs, and other animals, including non-human primates, are being widely used due to their persistent association in causing gastric complications. However, finding suitable animal models for in vivo experimentation to understand the pathophysiology of gastric cancer and MALT lymphoma is a complicated task. In this review, we summarized the most appropriate and latest information in the scientific literature to understand the role and importance of H. pylori infection animal models.

Keywords: Helicobacter pylori infection; Mongolian gerbils; animal model; gastric pathogenicity.

Publication types

  • Review