In Vitro and in Vivo Drug Studies With Three Agents of Central Nervous System Phaeohyphomycosis

Chemotherapy. 1987;33(2):129-40. doi: 10.1159/000238485.

Abstract

Amphotericin B (Amph B), 5-fluorocytosine (5-FC), ketoconazole (KTZ), fluconazole (FLZ), amorolfine (AMOR) and terbinafine (TER) were tested against 3 agents of central nervous system phaeohyphomycosis in vitro and in life-threatening infections in mice. The fungi studied were Cladosporium bantianum, Dactylaria constricta and Wangiella dermatitidis. The broadest protection against this group of fungi in mice was offered by 5-FC followed by Amph B and FLZ, then KTZ. AMOR and TER were inactive in vivo. The results of in vitro susceptibility testing had no predictive value. In contrast, the data obtained from the mouse models should be useful clinically.

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / microbiology
  • Fungi / drug effects*
  • Mice
  • Microbial Sensitivity Tests
  • Mycoses / drug therapy*
  • Mycoses / microbiology

Substances

  • Antifungal Agents