COVID-19 rapidly increases MDSCs and prolongs innate immune dysfunctions

Eur J Immunol. 2022 Oct;52(10):1676-1679. doi: 10.1002/eji.202249827. Epub 2022 Jun 24.


We used unsupervised immunophenotyping of blood leukocytes and measured cytokine production by innate immune cell exposed to LPS and R848. We show that COVID-19 induces a rapid, transient upregulation of myeloid-derived suppressor cells (MDSCs) accompanied by a rapid, sustained (up to 3 months) hyporesponsiveness of dendritic cells and monocytes. Blood MDSCs may represent biomarkers and targets for intervention strategies in COVID-19 patients.

Keywords: COVID-19; Cytokines; Dendritic cells; Monocytes; Myeloid-derived suppressor cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers
  • COVID-19*
  • Cytokines / pharmacology
  • Humans
  • Immune System Diseases*
  • Immunity, Innate
  • Lipopolysaccharides
  • Myeloid-Derived Suppressor Cells*


  • Biomarkers
  • Cytokines
  • Lipopolysaccharides