Comparison of effects of ingested medium- and long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides

Dig Dis Sci. 1987 May;32(5):481-6. doi: 10.1007/BF01296030.


In a double-blind, crossover study of the effect of ingested medium-chain triglyceride (MCT) and long-chain triglyceride (LCT) in six normal subjects, the gallbladder did not contract after ingestion of MCT but instead had significantly increased in volume at 2 hr after the meal. Plasma cholecystokinin (CCK) increased after the MCT meal, but gastrin, motilin, pancreatic polypeptide (PP), and GIP were unaffected. The long-chain triglyceride meal evoked a brisk and sustained gallbladder contraction, higher levels of CCK, and a significant increase in plasma PP and GIP levels.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Cholecystokinin / metabolism*
  • Double-Blind Method
  • Fat Emulsions, Intravenous / pharmacology
  • Female
  • Gallbladder / physiology*
  • Gastrointestinal Hormones / metabolism*
  • Humans
  • Male
  • Muscle Contraction
  • Pancreatic Polypeptide / metabolism
  • Triglycerides / pharmacology*


  • Fat Emulsions, Intravenous
  • Gastrointestinal Hormones
  • Triglycerides
  • Pancreatic Polypeptide
  • Cholecystokinin