Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity

Yuting Zhang; Xing Peng; Zhejun Sun; Chen Hu; Huihao Zhou; Jun Xu; Qiong Gu

doi:10.1016/j.fitote.2022.105233

Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity

Fitoterapia. 2022 Sep:161:105233. doi: 10.1016/j.fitote.2022.105233. Epub 2022 Jun 8.

Authors

Yuting Zhang¹, Xing Peng¹, Zhejun Sun¹, Chen Hu¹, Huihao Zhou¹, Jun Xu¹, Qiong Gu²

Affiliations

¹ Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
² Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: guqiong@mail.sysu.edu.cn.

PMID: 35690188
DOI: 10.1016/j.fitote.2022.105233

Abstract

The phytochemical investigation on Atractylodes chinensis afforded 15 polyacetylenes 1-15 and one meroterpenoid 16. Of the 16 isolates, compounds 4 and 9 are new ones, and compounds 8 and 16 are first reported from nature. In addition, the relative configuration of 1 and the available NMR data of compounds 1, 8, and 16 were first provided. Their structures were elucidated by extensive analysis of MS, UV, IR, and NMR spectroscopic data. Besides, all isolated compounds were evaluated for their effects on RANKL-induced osteoclastogenesis in BMMs. Among them, polyacetylenes 12-14 showed potent inhibitory activity with IC₅₀ values of 0.67 ± 0.05 μM, 0.72 ± 0.31 μM, and 2.40 ± 0.41 μM, respectively. The current work demonstrates the polyacetylenes are the main active constituents of A. chinensis against osteoclastogenesis.

Keywords: Atractylodes chinensis; Meroterpenoid; Osteoporosis; Polyacetylene.

MeSH terms

Atractylodes* / chemistry
Molecular Structure
Plant Extracts / chemistry
Polyacetylene Polymer
Polyynes / chemistry
Polyynes / pharmacology

Substances

Plant Extracts
Polyacetylene Polymer
Polyynes