A selective hybrid fluorescent sensor for fructose detection based on a phenylboronic acid and BODIPY-based hydrophobicity probe

Gengo Kashiwazaki; Ryo Watanabe; Akihiro Nishikawa; Koyori Kawamura; Takashi Kitayama; Takao Hibi

doi:10.1039/d2ra01569b

A selective hybrid fluorescent sensor for fructose detection based on a phenylboronic acid and BODIPY-based hydrophobicity probe

RSC Adv. 2022 May 18;12(24):15083-15090. doi: 10.1039/d2ra01569b. eCollection 2022 May 17.

Authors

Gengo Kashiwazaki¹, Ryo Watanabe¹, Akihiro Nishikawa¹, Koyori Kawamura², Takashi Kitayama¹, Takao Hibi²

Affiliations

¹ Major in Advanced Bioscience, Graduate School of Agriculture, Kindai University 3327-204, Nakamachi Nara Nara 631-8505 Japan kitayama@nara.kindai.ac.jp.
² Department of Bioscience and Biotechnology, Faculty of Bioscience and Biotechnology, Fukui Prefectural University 4-1-1 Matsuoka-Kenjojima, Eiheiji Fukui 910-1195 Japan hibi@fpu.ac.jp.

Abstract

Fructose is widely used in the food industry. However, it may be involved in diseases by generating harmful advanced glycation end-products. We have designed and synthesized a novel fluorescent probe for fructose detection by combining a phenylboronic acid group with a BODIPY-based hydrophobicity probe. This probe showed a linear fluorescence response to d-fructose concentration in the range of 100-1000 μM, with a detection limit of 32 μM, which is advantageous for the simple and sensitive determination of fructose.