Abstract
Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.
MeSH terms
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Cyclodextrins / pharmacology*
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Dextrins / pharmacology*
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Kinetics
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Organophosphates / antagonists & inhibitors
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Organophosphorus Compounds / antagonists & inhibitors*
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Organothiophosphorus Compounds / antagonists & inhibitors
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Sarin / antagonists & inhibitors*
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Soman / antagonists & inhibitors*
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Starch / pharmacology*
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alpha-Cyclodextrins*
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beta-Cyclodextrins*
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gamma-Cyclodextrins*
Substances
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Cyclodextrins
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Dextrins
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Organophosphates
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Organophosphorus Compounds
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Organothiophosphorus Compounds
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alpha-Cyclodextrins
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beta-Cyclodextrins
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gamma-Cyclodextrins
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Starch
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Soman
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VX
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Sarin
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betadex
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gamma-cyclodextrin
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tabun
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alpha-cyclodextrin