Risk factors for metabolic bone disease of prematurity: A meta-analysis

PLoS One. 2022 Jun 13;17(6):e0269180. doi: 10.1371/journal.pone.0269180. eCollection 2022.


Objective: To investigate the risk factors for metabolic bone disease of prematurity (MBDP), and to provide a reference for the prevention of MBDP.

Methods: The databases including China Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Data, and Weipu Periodical Database, PubMed, Web of Science, Embase, Cochrane Library and other databases were searched for studies on the risk factors for MBDP published up to June 18, 2021. RevMan 5.3 and Stata 14.1 software were used to perform a Meta analysis.

Results: A total of 15 articles were included, including 13 case-control studies, 1 current investigation, and 1 retrospective cohort study. There were 1,435 cases in the case group and 2,057 cases in the control group, with a total sample size of 3,492 cases. Meta analysis showed that risk factors for MBDP include birth weight <1000g (OR = 6.62, 95%CI: 2.28-19.25), gestational age <32 weeks (OR = 2.73, 95%CI: 1.07-6.95), septicemia (OR = 2.53, 95%CI: 1.69-3.79), parenteral nutrition time (OR = 4.04, 95%CI: 1.72-9.49), cholestasis (OR = 3.50, 95%CI: 1.49-8.23), intrauterine growth retardation (OR = 6.89, 95%CI: 3.81-12.44), while the birth weight(OR = 0.44, 95%CI: 0.21-0.90) and gestational age (OR = 0.57, 95%CI: 0.44-0.73)are the protective factors of MBDP.

Conclusion: Factors like birth weight <1000g, gestational age <32 weeks, septicemia, parenteral nutrition time, cholestasis, and intrauterine growth retardation may increase the risk of metabolic bone disease of prematurity.

Publication types

  • Meta-Analysis

MeSH terms

  • Birth Weight
  • Bone Diseases, Metabolic* / epidemiology
  • Bone Diseases, Metabolic* / metabolism
  • Cholestasis*
  • Female
  • Fetal Growth Retardation
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases*
  • Retrospective Studies
  • Risk Factors
  • Sepsis*

Grants and funding

The authors received no specific funding for this work.