Saliva Diagnostics

Annu Rev Anal Chem (Palo Alto Calif). 2022 Jun 13;15(1):107-121. doi: 10.1146/annurev-anchem-061020-123959.


Cancer remains one of the leading causes of death, and early detection of this disease is crucial for increasing survival rates. Although cancer can be diagnosed following tissue biopsy, the biopsy procedure is invasive; liquid biopsy provides an alternative that is more comfortable for the patient. While blood, urine, and cerebral spinal fluid can all be used as a source of liquid biopsy, saliva is an ideal source of body fluid that is readily available and easily collected in the most noninvasive manner. Characterization of salivary constituents in the disease setting provides critical data for understanding pathophysiology and the evaluation of diagnostic potential. The aim of saliva diagnostics is therefore to develop a rapid and noninvasive detection of oral and systemic diseases that could be used together with compact analysis systems in the clinic to facilitate point-of-care diagnostics.

Keywords: circulating biomarkers; saliva exosomics; saliva liquid biopsy; salivaomics; salivary exosomes.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomarkers, Tumor / analysis
  • Early Detection of Cancer
  • Humans
  • Liquid Biopsy
  • Neoplasms* / diagnosis
  • Saliva* / chemistry


  • Biomarkers, Tumor