Intermetallic cobalt-gallium targets for production of germanium radioisotopes

C J Kutyreff; T E Barnhart; Y H Lo; S Happel; R J Nickles; P A Ellison; E Aluicio-Sarduy; J W Engle

doi:10.1016/j.apradiso.2022.110307

Intermetallic cobalt-gallium targets for production of germanium radioisotopes

Appl Radiat Isot. 2022 Sep;187:110307. doi: 10.1016/j.apradiso.2022.110307. Epub 2022 May 28.

Authors

C J Kutyreff¹, T E Barnhart¹, Y H Lo¹, S Happel², R J Nickles¹, P A Ellison¹, E Aluicio-Sarduy¹, J W Engle³

Affiliations

¹ University of Wisconsin-Madison School of Medicine and Public Health, Department of Medical Physics, USA.
² TrisKem International, France.
³ University of Wisconsin-Madison School of Medicine and Public Health, Department of Medical Physics, USA; University of Wisconsin-Madison School of Medicine and Public Health, Department of Radiology, USA. Electronic address: jwengle@wisc.edu.

PMID: 35696750
DOI: 10.1016/j.apradiso.2022.110307

Abstract

Increasing interest in targeted radionuclide therapy motivates the development of new radionuclides. The unique emission spectrum from ⁷¹Ge make it an ideal candidate for probing microdosimetric effects of low energy electrons absent confounding photon dose. This work reports a novel intermetallic target of Co and Ga for accelerator production of no-carrier-added ^69/71Ge and a new method to isolate the Ge in high yields and purities.

Keywords: (69)Ge; (71)Ge; Positron emission tomography; Radionuclides; Targeted radionuclide therapy; Theranostic.

MeSH terms

Cobalt
Gallium Radioisotopes
Gallium*
Germanium*
Radioisotopes

Substances

Gallium Radioisotopes
Radioisotopes
Germanium
Cobalt
Gallium