What Dermatologists Should Know About Thiazides

Actas Dermosifiliogr. 2022 May;113(5):498-504. doi: 10.1016/j.ad.2021.12.015. Epub 2022 Jan 31.
[Article in English, Spanish]


Hydrochlorothiazide and other thiazide diuretics have been used for decades to treat high blood pressure, heart failure, and chronic kidney disease. Thiazides have been linked to photosensitivity with heterogeneous clinical manifestations and recovery times. Diagnosis can be aided by phototesting, photopatch testing, and skin biopsy. Long-term use of hydrochlorothiazide has been linked to an increased dose-dependent risk of certain types of skin cancer in recent years. In this review, we also look at other less common or lesser-known adverse effects of thiazide diuretics that have been described in isolated reports.

Keywords: Cáncer cutáneo; Fotosensibilidad; Hidroclorotiazida; Hydrochlorothiazide; Photosensitivity; Skin cancer; Thiazides; Tiazidas.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Dermatologists
  • Humans
  • Hydrochlorothiazide / adverse effects
  • Hypertension* / drug therapy
  • Sodium Chloride Symporter Inhibitors / therapeutic use
  • Thiazides* / adverse effects


  • Antihypertensive Agents
  • Sodium Chloride Symporter Inhibitors
  • Thiazides
  • Hydrochlorothiazide