Abstract
The effect of Piracetam on hypoxia-induced alterations of cerebral cortex electrogenesis is studied. The results showed protection. As this anti-hypoxidotic property could be linked to Piracetam influence on energy-metabolic processes in the brain, we studied the effect of this nootropic drug on local cerebral glucose utilization (LCGU) by means of a variant of the Sokoloff's technique. Our results showed that Piracetam enhances LCGU. We suggest that both effects, the functional and the metabolic one, are related.
MeSH terms
-
Animals
-
Brain / drug effects
-
Brain / metabolism*
-
Cerebral Cortex / drug effects
-
Cerebral Cortex / physiopathology*
-
Deoxy Sugars / metabolism*
-
Deoxyglucose / metabolism*
-
Electroencephalography
-
Energy Metabolism / drug effects
-
Hypoxia / physiopathology*
-
Hypoxia / prevention & control
-
Male
-
Pentobarbital / pharmacology
-
Piracetam / pharmacology*
-
Piracetam / therapeutic use
-
Pyrrolidinones / pharmacology*
-
Rats
-
Rats, Inbred Strains
-
Tissue Distribution
Substances
-
Deoxy Sugars
-
Pyrrolidinones
-
Deoxyglucose
-
Pentobarbital
-
Piracetam