Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors

Nicholas S Cho; Akifumi Hagiwara; Jingwen Yao; David A Nathanson; Robert M Prins; Chencai Wang; Catalina Raymond; Brandon R Desousa; Ajit Divakaruni; Danielle H Morrow; Phioanh L Nghiemphu; Albert Lai; Linda M Liau; Richard G Everson; Noriko Salamon; Whitney B Pope; Timothy F Cloughesy; Benjamin M Ellingson

doi:10.1002/nbm.4785

Amine-weighted chemical exchange saturation transfer magnetic resonance imaging in brain tumors

NMR Biomed. 2023 Jun;36(6):e4785. doi: 10.1002/nbm.4785. Epub 2022 Jun 29.

Authors

Nicholas S Cho^{1

2

3

4}, Akifumi Hagiwara^{1

2}, Jingwen Yao^{1

2

3}, David A Nathanson⁵, Robert M Prins⁶, Chencai Wang^{1

2}, Catalina Raymond^{1

2}, Brandon R Desousa⁵, Ajit Divakaruni⁵, Danielle H Morrow⁵, Phioanh L Nghiemphu^{7

8}, Albert Lai^{7

8}, Linda M Liau⁶, Richard G Everson⁶, Noriko Salamon², Whitney B Pope², Timothy F Cloughesy^{7

8}, Benjamin M Ellingson^{1

2

3

6

8

9}

Affiliations

¹ UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, California, USA.
² Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
³ Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, California, USA.
⁴ Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁵ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁶ Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁷ Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁸ UCLA Brain Tumor Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
⁹ Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

PMID: 35704275
DOI: 10.1002/nbm.4785

Abstract

Amine-weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) is particularly valuable as an amine- and pH-sensitive imaging technique in brain tumors, targeting the intrinsically high concentration of amino acids with exchangeable amine protons and reduced extracellular pH in brain tumors. Amine-weighted CEST MRI contrast is dependent on the glioma genotype, likely related to differences in degree of malignancy and metabolic behavior. Amine-weighted CEST MRI may provide complementary value to anatomic imaging in conventional and exploratory therapies in brain tumors, including chemoradiation, antiangiogenic therapies, and immunotherapies. Continual improvement and clinical testing of amine-weighted CEST MRI has the potential to greatly impact patients with brain tumors by understanding vulnerabilities in the tumor microenvironment that may be therapeutically exploited.

Keywords: Amine CEST; Brain Tumor; CEST EPI; Glioblastoma; Treatment Response; pH Imaging.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Amines* / chemistry
Brain Neoplasms* / chemistry
Brain Neoplasms* / diagnostic imaging
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Imaging / methods
Protons
Tumor Microenvironment

Substances

Amines
Protons

Abstract

Publication types

MeSH terms

Substances

Grants and funding