Distributed genetic architecture across the hippocampal formation implies common neuropathology across brain disorders

Nat Commun. 2022 Jun 15;13(1):3436. doi: 10.1038/s41467-022-31086-w.

Abstract

Despite its major role in complex human functions across the lifespan, most notably navigation, learning and memory, much of the genetic architecture of the hippocampal formation is currently unexplored. Here, through multivariate genome-wide association analysis in volumetric data from 35,411 white British individuals, we reveal 177 unique genetic loci with distributed associations across the hippocampal formation. We identify genetic overlap with eight brain disorders with typical onset at different stages of life, where common genes suggest partly age- and disorder-independent mechanisms underlying hippocampal pathology.

MeSH terms

  • Brain Diseases* / genetics
  • Genetic Loci
  • Genome-Wide Association Study*
  • Hippocampus
  • Humans
  • Polymorphism, Single Nucleotide
  • Whites