Exercise in the Genetic Arrhythmia Syndromes - A Review

Clin Sports Med. 2022 Jul;41(3):485-510. doi: 10.1016/j.csm.2022.02.008.


Provide a brief summary of your article (100-150 words; no references or figures/tables). The synopsis appears only in the table of contents and is often used by indexing services such as PubMed. Genetic arrhythmia syndromes are rare, yet harbor the potential for highly consequential, often unpredictable arrhythmias or sudden death events. There has been historical uncertainty regarding the correct advice to offer to affected patients who are reasonably wanting to participate in sporting and athletic endeavors. In some cases, this had led to abundantly cautious disqualifications, depriving individuals from participation unnecessarily. Societal guidance and expert opinion has evolved significantly over the last decade or 2, along with our understanding of the genetics and natural history of these conditions, and the emphasis has switched toward shared decision making with respect to the decision to participate or not, with patients and families becoming better informed, and willing participants in the decision making process. This review aims to give a brief update of the salient issues for the busy physician concerning these syndromes and to provide a framework for approaching their management in the otherwise aspirational or keen sports participant.

Keywords: Arrhythmia; Brugada; CPVT; Exercise; Genetic; LQTS; QT; SQTS.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac* / genetics
  • Arrhythmias, Cardiac* / therapy
  • Death, Sudden, Cardiac / prevention & control
  • Exercise
  • Humans
  • Sports*
  • Syndrome