SARS-CoV-2 infection in patients with inborn errors of immunity due to DNA repair defects

Acta Biochim Biophys Sin (Shanghai). 2022 Jun 25;54(6):836-846. doi: 10.3724/abbs.2022071.

Abstract

Clinical information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with inborn errors of immunity (IEI) during the current Coronavirus disease 2019 (COVID-19) pandemic is still limited. Proper DNA repair machinery is required for the development of the adaptive immune system, which provides specific and long-term protection against SARS-CoV-2. This review highlights the impact of SARS-CoV-2 infections on IEI patients with DNA repair disorders and summarizes susceptibility risk factors, pathogenic mechanisms, clinical manifestations and management strategies of COVID-19 in this special patient population.

Keywords: COVID-19; DNA repair mechanism; inborn errors of immunity; primary immunodeficiency.

Publication types

  • Review

MeSH terms

  • COVID-19*
  • DNA Repair
  • Humans
  • Pandemics / prevention & control
  • SARS-CoV-2

Grants and funding

This work was supported by the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650), the Swedish Research Council, the Swedish Cancer Society, and the Knut and Alice Wallenberg Foundation (KAW).