Current understanding of genomic stability maintenancein pluripotent stem cells

Acta Biochim Biophys Sin (Shanghai). 2022 May 25;54(6):858-863. doi: 10.3724/abbs.2022064.


Pluripotent stem cells (PSCs) are able to generate all cell types in the body and have wide applications in basic research and cell-based regenerative medicine. Maintaining stable genome in culture is the first priority for stem cell application in clinics. In addition, genomic instability in PSCs can cause developmental failure or abnormalities. Understanding how PSCs maintain genome stability is of critical importance. Due to their fundamental role in organism development, PSCs must maintain superior stable genome than differentiated cells. However, the underlying mechanisms are far from clear. Very limited studies suggest that PSCs utilize specific strategies and regulators to robustly improve genome stability. In this review, we summarize the current understandings of the unique properties of genome stability maintenance in PSCs.

Keywords: DNA damage response; genomic stability; pluripotent stem cell.

Publication types

  • Review

MeSH terms

  • Cell Differentiation / genetics
  • Genomic Instability
  • Humans
  • Pluripotent Stem Cells* / metabolism
  • Regenerative Medicine