Abstract
A rapid, sensitive and selective method for the determination in plasma and urine of nafimidone, a new antiepileptic drug, and its major metabolite, nafimidone alcohol, has been developed which uses a high-performance liquid chromatographic system and a fluorescence detector for nafimidone or ultraviolet detector for nafimidone alcohol. The detection limits for nafimidone and nafimidone alcohol are 5.0 and 12.5 ng/ml, respectively.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anticonvulsants / analysis*
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Anticonvulsants / blood
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Anticonvulsants / urine
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Chromatography, High Pressure Liquid
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Humans
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Imidazoles / analysis*
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Kinetics
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Naphazoline / analogs & derivatives
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Naphazoline / analysis*
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Naphazoline / blood
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Naphazoline / urine
Substances
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Anticonvulsants
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Imidazoles
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nafimidone alcohol
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Naphazoline
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nafimidone