High-performance liquid chromatographic determination of nafimidone and its major metabolite nafimidone alcohol in human plasma and urine

J Chromatogr. 1987 Mar 6;414(2):389-98. doi: 10.1016/0378-4347(87)80063-4.

Abstract

A rapid, sensitive and selective method for the determination in plasma and urine of nafimidone, a new antiepileptic drug, and its major metabolite, nafimidone alcohol, has been developed which uses a high-performance liquid chromatographic system and a fluorescence detector for nafimidone or ultraviolet detector for nafimidone alcohol. The detection limits for nafimidone and nafimidone alcohol are 5.0 and 12.5 ng/ml, respectively.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anticonvulsants / analysis*
  • Anticonvulsants / blood
  • Anticonvulsants / urine
  • Chromatography, High Pressure Liquid
  • Humans
  • Imidazoles / analysis*
  • Kinetics
  • Naphazoline / analogs & derivatives
  • Naphazoline / analysis*
  • Naphazoline / blood
  • Naphazoline / urine

Substances

  • Anticonvulsants
  • Imidazoles
  • nafimidone alcohol
  • Naphazoline
  • nafimidone