Uncommon and Difficult High-Grade Endometrial Carcinomas

Surg Pathol Clin. 2022 Jun;15(2):301-314. doi: 10.1016/j.path.2022.02.007. Epub 2022 May 20.


This article presents features of uncommon high-grade endometrial carcinomas that often pose a significant diagnostic challenge. An update on undifferentiated and dedifferentiated endometrial carcinoma is first provided, followed by discussions on more recently defined entities such as mesonephric-like carcinoma of the endometrium and gastric-type endometrial carcinomas. Finally, endometrial carcinoma with germ cell or trophoblastic-like components is discussed.

Keywords: Dedifferentiated endometrial carcinoma; Endometrial carcinoma with germ cell or trophoblastic-like components; Gastric-type endometrial carcinoma; Mesonephric-like carcinoma of the endometrium; Undifferentiated endometrial carcinoma.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor
  • Carcinoma* / diagnosis
  • Carcinoma* / pathology
  • Carcinoma, Endometrioid* / pathology
  • Endometrial Neoplasms* / diagnosis
  • Endometrial Neoplasms* / pathology
  • Endometrium / pathology
  • Female
  • Humans
  • Hyperplasia / pathology
  • Immunohistochemistry


  • Biomarkers, Tumor