Update on Mesenchymal Lesions of the Lower Female Genital Tract

Surg Pathol Clin. 2022 Jun;15(2):341-367. doi: 10.1016/j.path.2022.02.009. Epub 2022 May 20.


This article provides an update of the recent developments in mesenchymal tumors of lower genital tract. We focus on the characterization of recurrent molecular events in certain genital stromal tumors, for instance angiomyofibroblastomas and superficial myofibroblastomas. Moreover, fusions involving Tyrosine-kinases receptors (NTRK, FRFR1, RET, COL1A1-PDGFB) have been demonstrated in an emerging group of mesenchymal tumors characterized by a fibrosarcoma-like morphology and a predilection for uterine cervix of premenopausal women. We also cover the topic of smooth muscle tumors of the lower genital tract, which can be now classified using the same diagnostic criteria than their uterine counterpart..

Keywords: Cervix; Lipoblastoma-like tumor of the vulva; Mesenchymal lesions; NTRK; SMARCA4; SMARCB1; Sarcoma; Vagina; Vulva.

Publication types

  • Review

MeSH terms

  • Female
  • Fibrosarcoma* / pathology
  • Humans
  • Smooth Muscle Tumor*
  • Soft Tissue Neoplasms*
  • Uterine Neoplasms* / diagnosis
  • Uterus / pathology