The role of stereotactic radiosurgery in the management of petroclival meningioma: a systematic review

J Neurooncol. 2022 Aug;159(1):33-42. doi: 10.1007/s11060-022-04041-4. Epub 2022 Jun 18.

Abstract

Purpose: Petroclival meningioma (PM) is a challenging neuro oncology case and stereotactic radiosurgery (SRS) is proposed as one treatment option. This systematic review aimed to examine the role of SRS in treating PM cases.

Methods: We constructed a systematic review using the PRISMA guidelines using peer-reviewed English literature until 16 February 2022 from EuroPMC and PubMed. We used the terms petroclival meningioma, clival meningioma, apex petrous meningioma, spheno petroclival meningioma, stereotactic radiosurgery, radiosurgery, CyberKnife, Gamma Knife, linear accelerator, LINAC, and radiotherapy.

Results: 10 out of 266 studies were chosen for this systematic review, two of which are case reports. The study comprised 719 patients, 73.7% of whom were female (n = 530) and had a median age of 56.99 years (18-90 years). At the time of diagnosis, the median tumor volume was 6.07 cm3 (0.13-64.9 cm3). The tumors were frequently located near the petroclival junction (83.6%, n = 598). Following SRS, the median follow-up was 64.52 months (3-252 months). 46.5% of 719 PMs exhibited a decrease in tumor size. 46% and 7.5% showed no change and increase in tumor volume, respectively. At the last radiographic follow-up (7-21.2 years), tumor control with a median of 98.8% (85-100%). Complications occurred in 6% of patients, with hydrocephalus (2.2%) as the prevalent complication. The use of SRS as a primary treatment for petroclival cases was not associated with increased complication rate RR 0.62 (95% CI [0.11, 3.59], p = 0.59) but statistically correlated with clinical failure clinical failure RR 0.56 (95% CI [0.32, 0.98], p = 0.04).

Conclusions: We found a low number of complications following SRS intervention and has been effectively controlling tumor progression.

Keywords: Management; Petroclival meningioma; Stereotactic radiosurgery.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Meningeal Neoplasms* / complications
  • Meningeal Neoplasms* / radiotherapy
  • Meningeal Neoplasms* / surgery
  • Meningioma* / complications
  • Meningioma* / radiotherapy
  • Meningioma* / surgery
  • Middle Aged
  • Radiosurgery* / adverse effects
  • Retrospective Studies
  • Skull Base Neoplasms* / pathology
  • Skull Base Neoplasms* / radiotherapy
  • Skull Base Neoplasms* / surgery
  • Treatment Outcome