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Review
. 2022 Jun 1:10:813666.
doi: 10.3389/fchem.2022.813666. eCollection 2022.

Immunosensor of Nitrofuran Antibiotics and Their Metabolites in Animal-Derived Foods: A Review

Jingze Jia  1 , Hongxia Zhang  1 , Jiayi Qu  1 , Yuanfeng Wang  1 , Naifeng Xu  1
Affiliations
Review

Immunosensor of Nitrofuran Antibiotics and Their Metabolites in Animal-Derived Foods: A Review

Jingze Jia et al. Front Chem. .

Abstract

Nitrofuran antibiotics have been widely used in the prevention and treatment of animal diseases due to the bactericidal effect. However, the residual and accumulation of their metabolites in vivo can pose serious health hazards to both humans and animals. Although their usage in feeding and process of food-derived animals have been banned in many countries, their metabolic residues are still frequently detected in materials and products of animal-derived food. Many sensitive and effective detection methods have been developed to deal with the problem. In this work, we summarized various immunological methods for the detection of four nitrofuran metabolites based on different types of detection principles and signal molecules. Furthermore, the development trend of detection technology in animal-derived food is prospected.

Keywords: animal-derived foods; antibiotics; antibody; immunosensor; nitrofuran.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic diagram of the detection methods of nitrofurans and the delivery process in the food chain.
FIGURE 2
FIGURE 2
The structures of nitrofurans, their metabolites and commonly used derivatives. (A) The metabolism and derivation process of FZD; (B) metabolism and derivation process of NFZ; (C) metabolism and derivation process of NFT; (D) metabolism and derivation process of FTD.
FIGURE 3
FIGURE 3
The main principle diagrams of various immunoassays. (A) the main principle and operation process of ELISA; (B) the main principle and operation process of LFIA; (C) the main principle and operation process of FIA; (D) the main principle and operation process of CLIA.
See this image and copyright information in PMC

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