PGC-1 α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure

Lei Chen; Yuan Qin; Bilin Liu; Meng Gao; Anqi Li; Xue Li; Guohua Gong

doi:10.3389/fcell.2022.871357

PGC-1 α-Mediated Mitochondrial Quality Control: Molecular Mechanisms and Implications for Heart Failure

Front Cell Dev Biol. 2022 May 27:10:871357. doi: 10.3389/fcell.2022.871357. eCollection 2022.

Authors

Lei Chen¹, Yuan Qin^{1

2}, Bilin Liu¹, Meng Gao¹, Anqi Li¹, Xue Li¹, Guohua Gong¹

Affiliations

¹ Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
² Department of Pharmacy, Shanghai East Hospital, Tongji University, Shanghai, China.

Abstract

Mitochondria with structural and functional integrity are essential for maintaining mitochondrial function and cardiac homeostasis. It is involved in the pathogenesis of many diseases. Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α), acted as a transcriptional cofactor, is abundant in the heart, which modulates mitochondrial biogenesis and mitochondrial dynamics and mitophagy to sustain a steady-state of mitochondria. Cumulative evidence suggests that dysregulation of PGC-1α is closely related to the onset and progression of heart failure. PGC-1α deficient-mice can lead to worse cardiac function under pressure overload compared to sham. Here, this review mainly focuses on what is known about its regulation in mitochondrial functions, as well as its crucial role in heart failure.

Keywords: PGC-1α; heart failure; mitochondrial biogenesis; mitochondrial dynamics; mitochondrial quality control.

Publication types

Review