Metastasis of Renal Cell Carcinoma to the Stomach Twenty One Years from Initial Diagnosis

Ulster Med J. 2022 May;91(2):95-97. Epub 2022 Jun 15.

Abstract

A female in her 80's presented to our Emergency Department following a fall. She reported general malaise, weight loss and raised inflammatory markers. Background included renal cell carcinoma 21 years previous, managed with radical nephrectomy. During her inpatient stay she had an episode of haematemesis. Upper GI endoscopy revealed a 3cm polypoidal lesion on the greater curve of the upper stomach. This had an irregular pit pattern endoscopically and was friable. Multiple biopsies revealed metastatic clear cell carcinoma of renal origin; the same sub-type as her previous renal tumour. This is a rare manifestation of metastatic renal cell carcinoma and from literature review, is only the 2nd case we can find with a lag time of >20 years from the initial diagnosis to presenting with metastatic gastric disease.

Keywords: Gastric Disease; Gastrointestinal Bleeding.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Carcinoma, Renal Cell* / diagnosis
  • Carcinoma, Renal Cell* / pathology
  • Carcinoma, Renal Cell* / surgery
  • Female
  • Humans
  • Kidney Neoplasms* / diagnosis
  • Kidney Neoplasms* / pathology
  • Kidney Neoplasms* / surgery
  • Nephrectomy
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / pathology
  • Stomach Neoplasms* / surgery