Frontal sinus obliteration with beta-tricalcium phosphate putty: case series with long-term radiological follow up

J Laryngol Otol. 2023 Feb;137(2):163-168. doi: 10.1017/S0022215122001487. Epub 2022 Jun 20.


Objectives: Frontal sinus obliteration is often performed using fat, autologous bone or a range of synthetic materials. This paper reports the long-term clinical and radiological outcomes of frontal sinus obliteration using beta-tricalcium phosphate putty.

Methods: A retrospective audit was performed of patients who underwent frontal sinus obliteration with beta-tricalcium phosphate putty. Patient-, disease- and procedure-related data were collected. Pre- and post-operative computed tomography scans were reviewed to assess bone integration.

Results: Four patients underwent frontal sinus obliteration using beta-tricalcium phosphate putty for treatment of a cerebrospinal leak, mucocele and recalcitrant frontal sinusitis. All patients had disease resolution, with no intra- or post-operative complications reported in the 16.5-month follow up. Post-operative computed tomography scans confirmed native bone obliteration of the frontonasal ducts in all patients.

Conclusion: Beta-tricalcium phosphate putty is a safe and effective option for bone obliteration of the frontal sinus in a range of pathologies, including cerebrospinal fluid leak.

Keywords: Bone Substitute; Cerebrospinal Fluid Leak; Frontal Sinus; Frontal Sinusitis; Mucocele.

MeSH terms

  • Follow-Up Studies
  • Frontal Sinus* / pathology
  • Frontal Sinusitis* / pathology
  • Frontal Sinusitis* / surgery
  • Humans
  • Retrospective Studies


  • beta-tricalcium phosphate