Gatekeeping astrocyte identity

Elife. 2022 Jun 20:11:e80232. doi: 10.7554/eLife.80232.

Abstract

New findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons.

Keywords: PTBP1; astrocyte; astrocyte-to-neuron conversion; brain repair; lineage reprogramming; mouse; neuroscience; parkinson's disease; regenerative medicine; stem cells.

Publication types

  • Editorial

MeSH terms

  • Astrocytes* / metabolism
  • Cells, Cultured
  • Dopaminergic Neurons / metabolism
  • Gatekeeping*