Advances in SLE classification criteria

J Autoimmun. 2022 Oct;132:102845. doi: 10.1016/j.jaut.2022.102845. Epub 2022 Jun 17.


This year, the American College of Rheumatology (ACR) 1982 classification criteria for systemic lupus erythematosus (SLE) celebrate their 40th anniversary. From this start, the quest for optimal SLE criteria has led to the 1997 ACR update, the 2012 publication of the Systemic Lupus International Collaborating Clinics (SLICC) criteria, and, in 2019, the European League Against Rheumatism (EULAR)/ACR classification criteria. The latter have since been externally validated in more than two dozen studies and have become the gold standard inclusion criterion of SLE clinical trials. This comprehensive review attempts to follow the evolving success story of SLE classification, highlighting relevant decisions and their rationale, and discussing consequences for the way SLE is defined and managed.

Keywords: Classification criteria; Clinical trials; Sensitivity; Specificity; Systemic lupus erythematosus.

Publication types

  • Review

MeSH terms

  • Humans
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Erythematosus, Systemic* / therapy
  • Rheumatic Diseases*
  • Rheumatology*
  • United States