Now is it time to implement spacers in cervical cancer brachytherapy?

J Radiat Res. 2022 Jul 19;63(4):696-698. doi: 10.1093/jrr/rrac031.


Although the international study on MRI-guided brachytherapy in cervical cancer (EMBRACE-I) demonstrated excellent local control regardless of the T stage, up to 14.6% of grade 3-5 late radiation-related toxicities were observed, which is unacceptable. While the efficacy of hydrogel spacers has been established in prostate radiotherapy, its implementation speed in cervical cancer brachytherapy is relatively slow, despite the fact that several articles have reported its efficacy in cervical cancer brachytherapy. The authors believe that using a spacer in cervical cancer brachytherapy and brachytherapy for other gynecologic malignancies will reduce late radiation-related toxicity and improve patients' quality of life; therefore, its rapid implementation is required.

Keywords: image-guided adaptive brachytherapy (IGABT); spacer; uterine cervical cancer.

MeSH terms

  • Brachytherapy*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Quality of Life
  • Radiation Injuries*
  • Radiotherapy Dosage
  • Radiotherapy, Image-Guided*
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / radiotherapy