Osteosarcoma is the most common malignant osteosarcoma, and most developing countries face great challenges in the diagnosis due to the lack of medical resources. Magnetic resonance imaging (MRI) has always been an important tool for the detection of osteosarcoma, but it is a time-consuming and labor-intensive task for doctors to manually identify MRI images. It is highly subjective and prone to misdiagnosis. Existing computer-aided diagnosis methods of osteosarcoma MRI images focus only on accuracy, ignoring the lack of computing resources in developing countries. In addition, the large amount of redundant and noisy data generated during imaging should also be considered. To alleviate the inefficiency of osteosarcoma diagnosis faced by developing countries, this paper proposed an artificial intelligence multiprocessing scheme for pre-screening, noise reduction, and segmentation of osteosarcoma MRI images. For pre-screening, we propose the Slide Block Filter to remove useless images. Next, we introduced a fast non-local means algorithm using integral images to denoise noisy images. We then segmented the filtered and denoised MRI images using a U-shaped network (ETUNet) embedded with a transformer layer, which enhances the functionality and robustness of the traditional U-shaped architecture. Finally, we further optimized the segmented tumor boundaries using conditional random fields. This paper conducted experiments on more than 70,000 MRI images of osteosarcoma from three hospitals in China. The experimental results show that our proposed methods have good results and better performance in pre-screening, noise reduction, and segmentation.