Objective: To explore relationship between postoperative serum caveolin-1 contents after open reduction and internal fixation and delayed healing of tibial fracture patients.
Methods: From April 2018 to June 2020, 134 tibial fracture patients underwent open reduction and internal fixation were included, and divided into delayed healing group and normal healing group according to fracture healing condition. Contents of serum caveolin-1 protein before operation, 1, 4, 8, 12 weeks after operation between two groups were compared. Influencing factors of delayed healing was analyzed by Logistic regression model, and predictive value of serum caveolin-1 protein on delayed healing was analyzed by receiver operating characteristic(ROC) curve.
Results: Fracture healing was evaluated at 4 months after fracture, 93 patients healed well and 41 patients delayed heal. At 1, 4, 8 and 12 weeks, content of serum caveolin-1 protein in delayed healing group was lower than that of normal healing group(P<0.05). There were statistical difference in smoking, diabetes, open fracture and Gutlio Ⅲ fracture between delayed healing group and normal healing group(P<0.05). Smoking, diabetes, open fracture, Gustlio Ⅲ fracture, decrease of serum caveolin-1 protein at 4 and 8 weeks after operation were risk factor of delayed healing by Logistic analysis(P<0.05). By ROC curve analysis, content of serum caveolin-1 protein had predictive value for delayed fracture, the best cut-off values were 12.45 ng/ml and 12.52 ng/ml respectively, corresponding sensitivity were 45.34%, 43.90%, and specificity were 80.65% and 87.10% (P<0.05).
Conclusion: Decrease of serum caveolin-1 protein content at 4 and 8 weeks after open reduction and internal fixation for tibia fracture patients were related with delayed healing. Detection of serum caveolin-1 protein content at 4 and 8 weeks after operation has predictive value for delayed healing.
Keywords: Caveolin-1; Fracture healing; Open fracture reduction; Tibial fracture.