Isolation and Characterization of Novel Reassortant Influenza A(H10N7) Virus in a Harbor Seal, British Columbia, Canada

Emerg Infect Dis. 2022 Jul;28(7):1480-1484. doi: 10.3201/eid2807.212302.


We isolated a novel reassortant influenza A(H10N7) virus from a harbor seal in British Columbia, Canada, that died from bronchointerstitial pneumonia. The virus had unique genome constellations involving lineages from North America and Eurasia and polymerase basic 2 segment D701N mutation, associated with adaptation to mammals.

Keywords: British Columbia; Canada; H10N7; avian influenza; harbor seals; influenza; influenza A virus; reassortment; viruses; whole-genome sequencing.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • British Columbia / epidemiology
  • DNA Viruses
  • Humans
  • Influenza A Virus, H10N7 Subtype* / genetics
  • Influenza in Birds*
  • Influenza, Human* / epidemiology
  • Orthomyxoviridae Infections* / epidemiology
  • Orthomyxoviridae Infections* / veterinary
  • Phoca*
  • Phylogeny
  • Reassortant Viruses / genetics