Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors

doi:10.1001/jamanetworkopen.2022.18183

. 2022 Jun 1;5(6):e2218183.

doi: 10.1001/jamanetworkopen.2022.18183.

Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors

Dongyu Zhang^{1

2}, Christiaan Leeuwenburgh³, Daohong Zhou⁴, Yan Gong⁵, Marco Pahor³, Jonathan D Licht^{2

6}, Dejana Braithwaite^{1

2

7}

Affiliations

¹ Department of Epidemiology, University of Florida College of Public Health and Health Professions, Gainesville.
² University of Florida Health Cancer Center, Gainesville.
³ Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville.
⁴ Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio.
⁵ Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville.
⁶ Division of Hematology and Oncology, University of Florida Health Cancer Center, Gainesville.
⁷ Department of Surgery, University of Florida College of Medicine, Gainesville.

PMID: 35731518
PMCID: PMC9218849
DOI: 10.1001/jamanetworkopen.2022.18183

Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors

Dongyu Zhang et al. JAMA Netw Open. 2022.

. 2022 Jun 1;5(6):e2218183.

doi: 10.1001/jamanetworkopen.2022.18183.

Authors

Dongyu Zhang^{1

2}, Christiaan Leeuwenburgh³, Daohong Zhou⁴, Yan Gong⁵, Marco Pahor³, Jonathan D Licht^{2

6}, Dejana Braithwaite^{1

2

7}

Affiliations

¹ Department of Epidemiology, University of Florida College of Public Health and Health Professions, Gainesville.
² University of Florida Health Cancer Center, Gainesville.
³ Department of Aging and Geriatric Research, University of Florida College of Medicine, Gainesville.
⁴ Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio.
⁵ Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville.
⁶ Division of Hematology and Oncology, University of Florida Health Cancer Center, Gainesville.
⁷ Department of Surgery, University of Florida College of Medicine, Gainesville.

PMID: 35731518
PMCID: PMC9218849
DOI: 10.1001/jamanetworkopen.2022.18183

Abstract

This cohort study examines the association between biological aging and all-cause and cardiovascular disease–specific death rates among individuals with cancer.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Gong reported receiving grants from the National Institutes of Health (NIH) outside the submitted work. Dr Pahor reported receiving grants from the NIH during the conduct of the study. No other disclosures were reported.

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References

1. Age and Cancer Risk . Accessed December 23, 2021. https://www.cancer.gov/about-cancer/causes-prevention/risk/age
1. Handforth C, Clegg A, Young C, et al. . The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091-1101. doi:10.1093/annonc/mdu540 - DOI - PubMed
1. Wang S, Prizment A, Thyagarajan B, Blaes A. Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment. Cancers (Basel). 2021;13(3):427. doi:10.3390/cancers13030427 - DOI - PMC - PubMed
1. Sturgeon KM, Deng L, Bluethmann SM, et al. . A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur Heart J. 2019;40(48):3889-3897. doi:10.1093/eurheartj/ehz766 - DOI - PMC - PubMed
1. Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study. PLoS Med. 2018;15(12):e1002718. doi:10.1371/journal.pmed.1002718 - DOI - PMC - PubMed

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[1] Age and Cancer Risk . Accessed December 23, 2021. https://www.cancer.gov/about-cancer/causes-prevention/risk/age

[2] Age and Cancer Risk . Accessed December 23, 2021. https://www.cancer.gov/about-cancer/causes-prevention/risk/age

[3] Handforth C, Clegg A, Young C, et al. . The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091-1101. doi:10.1093/annonc/mdu540 - DOI - PubMed

[4] Handforth C, Clegg A, Young C, et al. . The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol. 2015;26(6):1091-1101. doi:10.1093/annonc/mdu540 - DOI - PubMed

[5] Wang S, Prizment A, Thyagarajan B, Blaes A. Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment. Cancers (Basel). 2021;13(3):427. doi:10.3390/cancers13030427 - DOI - PMC - PubMed

[6] Wang S, Prizment A, Thyagarajan B, Blaes A. Cancer treatment-induced accelerated aging in cancer survivors: biology and assessment. Cancers (Basel). 2021;13(3):427. doi:10.3390/cancers13030427 - DOI - PMC - PubMed

[7] Sturgeon KM, Deng L, Bluethmann SM, et al. . A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur Heart J. 2019;40(48):3889-3897. doi:10.1093/eurheartj/ehz766 - DOI - PMC - PubMed

[8] Sturgeon KM, Deng L, Bluethmann SM, et al. . A population-based study of cardiovascular disease mortality risk in US cancer patients. Eur Heart J. 2019;40(48):3889-3897. doi:10.1093/eurheartj/ehz766 - DOI - PMC - PubMed

[9] Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study. PLoS Med. 2018;15(12):e1002718. doi:10.1371/journal.pmed.1002718 - DOI - PMC - PubMed

[10] Liu Z, Kuo PL, Horvath S, Crimmins E, Ferrucci L, Levine M. A new aging measure captures morbidity and mortality risk across diverse subpopulations from NHANES IV: a cohort study. PLoS Med. 2018;15(12):e1002718. doi:10.1371/journal.pmed.1002718 - DOI - PMC - PubMed

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Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors

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Analysis of Biological Aging and Risks of All-Cause and Cardiovascular Disease-Specific Death in Cancer Survivors

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